B box and SPRY domain-containing protein (BSPRY)
Homo sapiens — UniProt Q5W0U4
Data last refreshed: (UniProt release unknown)
Key facts
B box and SPRY domain-containing protein (BSPRY) is a protein from Homo sapiens identified by UniProt accession Q5W0U4, 402 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q5W0U4; gene symbol BSPRY.
- Organism: Homo sapiens.
- Length: 402 amino acids.
- Top disease associations (Open Targets): blood lead measurement, body fat percentage and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | B box and SPRY domain-containing protein |
|---|---|
| UniProt accession | Q5W0U4 |
| Gene | BSPRY |
| Organism | Homo sapiens |
| Length | 402 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- blood lead measurement · score 0.17
- body fat percentage · score 0.14
- leukocyte count · score 0.12
- appendicular lean mass · score 0.08
- neutrophil count · score 0.06
- blood protein measurement · score 0.05
- immune deficiency, familial variable · score 0.05
- classic Hodgkin lymphoma · score 0.05
- Hodgkins lymphoma · score 0.05
- hyper-IgM syndrome type 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5W0U4-F1 | alphafold | PREDICTED | 91.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5W0U4.
Amino-acid sequence (402 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BSPRY?
The strongest Open Targets associations for BSPRY are blood lead measurement, body fat percentage, leukocyte count, appendicular lean mass and neutrophil count.
How long is the BSPRY protein?
The Homo sapiens BSPRY protein (UniProt Q5W0U4) is 402 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5W0U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5W0U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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