FHF complex subunit HOOK interacting protein 2A (FHIP2A)
Homo sapiens — UniProt Q5W0V3
Data last refreshed: (UniProt release unknown)
Key facts
FHF complex subunit HOOK interacting protein 2A (FHIP2A) is a protein from Homo sapiens identified by UniProt accession Q5W0V3, 765 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q5W0V3; gene symbol FHIP2A.
- Organism: Homo sapiens.
- Length: 765 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, neurofibrillary tangles measurement and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FHF complex subunit HOOK interacting protein 2A |
|---|---|
| UniProt accession | Q5W0V3 |
| Gene | FHIP2A |
| Organism | Homo sapiens |
| Length | 765 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.45
- neurofibrillary tangles measurement · score 0.31
- attention deficit hyperactivity disorder · score 0.30
- bipolar disorder · score 0.30
- PHF-tau measurement · score 0.29
- syndromic intellectual disability · score 0.26
- alcohol consumption measurement · score 0.12
- retinitis pigmentosa · score 0.04
- Abnormality of refraction · score 0.04
- cone-rod synaptic disorder syndrome, congenital nonprogressive · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5W0V3-F1 | alphafold | PREDICTED | 79.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5W0V3.
Amino-acid sequence (765 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FHIP2A?
The strongest Open Targets associations for FHIP2A are alkaline phosphatase measurement, neurofibrillary tangles measurement, attention deficit hyperactivity disorder, bipolar disorder and PHF-tau measurement.
How long is the FHIP2A protein?
The Homo sapiens FHIP2A protein (UniProt Q5W0V3) is 765 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5W0V3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5W0V3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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