About BTB/POZ domain-containing protein 8
BTB/POZ domain-containing protein 8 (BTBD8) is a protein
from Homo sapiens identified by UniProt accession
Q5XKL5, 1792 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (64)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.33
- inflammatory bowel disease · score 0.31
- Red cell distribution width · score 0.21
- serum alanine aminotransferase measurement · score 0.20
- mean corpuscular hemoglobin concentration · score 0.16
- lymphocyte percentage of leukocytes · score 0.06
- neutrophil count · score 0.05
- glioblastoma multiforme · score 0.04
- atypical teratoid rhabdoid tumor · score 0.04
- ependymoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q5XKL5.
Amino-acid sequence (1792 residues)
MARCGEGSAA PMVLLGSAGV CSKGLQRKGP CERRRLKATV SEQLSQDLLR LLREEFHTDV TFSVGCTLFK AHKAVLLARV PDFYFHTIGQ TSNSLTNQEP IAVENVEALE FRTFLQIIYS SNRNIKNYEE EILRKKIMEI GISQKQLDIS FPKCENSSDC SLQKHEIPED ISDRDDDFIS NDNYDLEPAS ELGEDLLKLY VKPCCPDIDI FVDGKRFKAH RAILSARSSY FAAMLSGCWA ESSQEYVTLQ GISHVELNVM MHFIYGGTLD IPDKTNVGQI LNMADMYGLE GLKEVAIYIL RRDYCNFFQK PVPRTLTSIL ECLIIAHSVG VESLFADCMK WIVKHFARFW SERSFANIPP EIQKSCLNML IQSLNDKNAA FLLMESDRLI ISLPRVKWTE AALTMASQLQ EKCIAFIVDN FSKIIQSENF ALLLQSQAMS STADLLDTIL KAIEENITTE NSCSLLMALD TLLNSDSTKE MGFTCKIQAL RDKLWIFLVQ SFYAVRHTES WKLMSTDDQQ KIQAAAFDKG DDRRLGKKPI FSSSQQRKQV SDSGDIKIKS WRGNNKKECW SYLSTNKKMK SDGLGASGHS SSTNRNSINK TLKQDDVKEK DGTKIASKIT KELKTGGKNV SGKPKTVTKS KTENGDKARL ENMSPRQVVE RSATAAAAAT GQKNLLNGKG VRNQEGQISG ARPKVLTGNL NVQAKAKPLK KATGKDSPCL SIAGPSSRST DSSMEFSIST ECLDEPKENG STEEEKPSGH KLSFCDSPGQ MMKNSVDSVK NSTVAIKSRP VSRVTNGTSN KKSIHEQDTN VNNSVLKKVS GKGCSEPVPQ AILKKRGTSN GCTAAQQRTK STPSNLTKTQ GSQGESPNSV KSSVSSRQSD ENVAKLDHNT TTEKQAPKRK MVKQVHTALP KVNAKIVAMP KNLNQSKKGE TLNNKDSKQK MPPGQVISKT QPSSQRPLKH ETSTVQKSMF HDVRDNNNKD SVSEQKPHKP LINLASEISD AEALQSSCRP DPQKPLNDQE KEKLALECQN ISKLDKSLKH ELESKQICLD KSETKFPNHK ETDDCDAANI CCHSVGSDNV NSKFYSTTAL KYMVSNPNEN SLNSNPVCDL DSTSAGQIHL ISDRENQVGR KDTNKQSSIK CVEDVSLCNP ERTNGTLNSA QEDKKSKVPV EGLTIPSKLS DESAMDEDKH ATADSDVSSK CFSGQLSEKN SPKNMETSES PESHETPETP FVGHWNLSTG VLHQRESPES DTGSATTSSD DIKPRSEDYD AGGSQDDDGS NDRGISKCGT MLCHDFLGRS SSDTSTPEEL KIYDSNLRIE VKMKKQSNND LFQVNSTSDD EIPRKRPEIW SRSAIVHSRE RENIPRGSVQ FAQEIDQVSS SADETEDERS EAENVAENFS ISNPAPQQFQ GIINLAFEDA TENECREFSA TKKFKRSVLL SVDECEELGS DEGEVHTPFQ ASVDSFSPSD VFDGISHEHH GRTCYSRFSR ESEDNILECK QNKGNSVCKN ESTVLDLSSI DSSRKNKQSV SATEKKNTID VLSSRSRQLL REDKKVNNGS NVENDIQQRS KFLDSDVKSQ ERPCHLDLHQ REPNSDIPKN SSTKSLDSFR SQVLPQEGPV KESHSTTTEK ANIALSAGDI DDCDTLAQTR MYDHRPSKTL SPIYEMDVIE AFEQKVESET HVTDMDFEDD QHFAKQDWTL LKQLLSEQDS NLDVTNSVPE DLSLAQYLIN QTLLLARDSS KPQGITHIDT LNRWSELTSP LDSSASITMA SFSSEDCSPQ GEWTILELET QH
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