Homeobox protein orthopedia (OTP)
Homo sapiens — UniProt Q5XKR4
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein orthopedia (OTP) is a protein from Homo sapiens identified by UniProt accession Q5XKR4, 325 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.
- UniProt accession: Q5XKR4; gene symbol OTP.
- Organism: Homo sapiens.
- Length: 325 amino acids.
- Top disease associations (Open Targets): platelet component distribution width, mean platelet volume and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein orthopedia |
|---|---|
| UniProt accession | Q5XKR4 |
| Gene | OTP |
| Organism | Homo sapiens |
| Length | 325 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (125)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.17
- mean platelet volume · score 0.16
- platelet count · score 0.08
- MODY · score 0.07
- obesity due to melanocortin 4 receptor deficiency · score 0.07
- aspartate aminotransferase measurement · score 0.07
- short stature due to primary acid-labile subunit deficiency · score 0.07
- heel bone mineral density · score 0.06
- urate measurement · score 0.06
- monocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5XKR4-F1 | alphafold | PREDICTED | 60.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5XKR4.
Amino-acid sequence (325 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OTP?
The strongest Open Targets associations for OTP are platelet component distribution width, mean platelet volume, platelet count, MODY and obesity due to melanocortin 4 receptor deficiency.
How long is the OTP protein?
The Homo sapiens OTP protein (UniProt Q5XKR4) is 325 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5XKR4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5XKR4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.