AP-1 complex-associated regulatory protein (AP1AR)
Homo sapiens — UniProt Q63HQ0
Data last refreshed: (UniProt release unknown)
Key facts
AP-1 complex-associated regulatory protein (AP1AR) is a protein from Homo sapiens identified by UniProt accession Q63HQ0, 302 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q63HQ0; gene symbol AP1AR.
- Organism: Homo sapiens.
- Length: 302 amino acids.
- Top disease associations (Open Targets): protein measurement, rheumatoid arthritis and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | AP-1 complex-associated regulatory protein |
|---|---|
| UniProt accession | Q63HQ0 |
| Gene | AP1AR |
| Organism | Homo sapiens |
| Length | 302 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.22
- rheumatoid arthritis · score 0.16
- adolescent idiopathic scoliosis · score 0.15
- body mass index · score 0.09
- mathematical ability · score 0.07
- body height · score 0.07
- insomnia measurement · score 0.06
- serum gamma-glutamyl transferase measurement · score 0.05
- lymphocyte count · score 0.05
- autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q63HQ0-F1 | alphafold | PREDICTED | 64.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q63HQ0.
Amino-acid sequence (302 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AP1AR?
The strongest Open Targets associations for AP1AR are protein measurement, rheumatoid arthritis, adolescent idiopathic scoliosis, body mass index and mathematical ability.
How long is the AP1AR protein?
The Homo sapiens AP1AR protein (UniProt Q63HQ0) is 302 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q63HQ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q63HQ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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