Little elongation complex subunit 2 (ICE2)
Homo sapiens — UniProt Q659A1
Data last refreshed: (UniProt release unknown)
Key facts
Little elongation complex subunit 2 (ICE2) is a protein from Homo sapiens identified by UniProt accession Q659A1, 982 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q659A1; gene symbol ICE2.
- Organism: Homo sapiens.
- Length: 982 amino acids.
- Top disease associations (Open Targets): eosinophil count, calcium measurement and eosinophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Little elongation complex subunit 2 |
|---|---|
| UniProt accession | Q659A1 |
| Gene | ICE2 |
| Organism | Homo sapiens |
| Length | 982 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.33
- calcium measurement · score 0.26
- eosinophil percentage of leukocytes · score 0.25
- annexin A2 measurement · score 0.23
- age at menarche · score 0.22
- body height · score 0.20
- puberty onset measurement · score 0.17
- age at voice drop · score 0.17
- Intellectual disability · score 0.14
- Seizure · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q659A1-F1 | alphafold | PREDICTED | 65.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q659A1.
Amino-acid sequence (982 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ICE2?
The strongest Open Targets associations for ICE2 are eosinophil count, calcium measurement, eosinophil percentage of leukocytes, annexin A2 measurement and age at menarche.
How long is the ICE2 protein?
The Homo sapiens ICE2 protein (UniProt Q659A1) is 982 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q659A1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q659A1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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