DDB1- and CUL4-associated factor 15 (DCAF15)
Homo sapiens — UniProt Q66K64
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 15 (DCAF15) is a protein from Homo sapiens identified by UniProt accession Q66K64, 600 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q66K64; gene symbol DCAF15.
- Organism: Homo sapiens.
- Length: 600 amino acids.
- Top disease associations (Open Targets): blood protein measurement, acute myeloid leukemia and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 15 |
|---|---|
| UniProt accession | Q66K64 |
| Gene | DCAF15 |
| Organism | Homo sapiens |
| Length | 600 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.20
- acute myeloid leukemia · score 0.08
- hepatocellular carcinoma · score 0.08
- autosomal recessive spondylocostal dysostosis · score 0.07
- autosomal dominant spondylocostal dysostosis · score 0.06
- neuroblastoma · score 0.06
- brachyolmia, Maroteaux type · score 0.05
- autosomal dominant brachyolmia · score 0.05
- spondyloepiphyseal dysplasia tarda, autosomal dominant · score 0.04
- Becker nevus syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q66K64-F1 | alphafold | PREDICTED | 77.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q66K64.
Amino-acid sequence (600 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF15?
The strongest Open Targets associations for DCAF15 are blood protein measurement, acute myeloid leukemia, hepatocellular carcinoma, autosomal recessive spondylocostal dysostosis and autosomal dominant spondylocostal dysostosis.
How long is the DCAF15 protein?
The Homo sapiens DCAF15 protein (UniProt Q66K64) is 600 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q66K64 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q66K64 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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