Transmembrane protein 198 (TMEM198)
Homo sapiens — UniProt Q66K66
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 198 (TMEM198) is a protein from Homo sapiens identified by UniProt accession Q66K66, 360 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q66K66; gene symbol TMEM198.
- Organism: Homo sapiens.
- Length: 360 amino acids.
- Top disease associations (Open Targets): PR interval, cortical thickness and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 198 |
|---|---|
| UniProt accession | Q66K66 |
| Gene | TMEM198 |
| Organism | Homo sapiens |
| Length | 360 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- PR interval · score 0.15
- cortical thickness · score 0.12
- body height · score 0.08
- diastolic blood pressure · score 0.08
- COVID-19 · score 0.01
- myxosarcoma · score 0.01
- diabetes mellitus · score 0.00
- acute lymphoblastic leukemia · score 0.00
- Crohn's disease · score 0.00
- breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q66K66-F1 | alphafold | PREDICTED | 75.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q66K66.
Amino-acid sequence (360 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM198?
The strongest Open Targets associations for TMEM198 are PR interval, cortical thickness, body height, diastolic blood pressure and COVID-19.
How long is the TMEM198 protein?
The Homo sapiens TMEM198 protein (UniProt Q66K66) is 360 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q66K66 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q66K66 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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