Carboxypeptidase Z (CPZ)
Homo sapiens — UniProt Q66K79
Data last refreshed: (UniProt release unknown)
Key facts
Carboxypeptidase Z (CPZ) is a protein from Homo sapiens identified by UniProt accession Q66K79, 652 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.
- UniProt accession: Q66K79; gene symbol CPZ.
- Organism: Homo sapiens.
- Length: 652 amino acids.
- Top disease associations (Open Targets): body height, appendicular lean mass and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Carboxypeptidase Z |
|---|---|
| UniProt accession | Q66K79 |
| Gene | CPZ |
| Organism | Homo sapiens |
| Length | 652 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (138)
Diseases linked to this target (Open Targets).
- body height · score 0.56
- appendicular lean mass · score 0.38
- neurodegenerative disease · score 0.37
- body fat distribution · score 0.37
- forced expiratory volume · score 0.33
- Short stature · score 0.32
- sitting height measurement · score 0.32
- neuroblastoma · score 0.31
- Abnormality of refraction · score 0.27
- vital capacity · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q66K79-F1 | alphafold | PREDICTED | 84.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q66K79.
Amino-acid sequence (652 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CPZ?
The strongest Open Targets associations for CPZ are body height, appendicular lean mass, neurodegenerative disease, body fat distribution and forced expiratory volume.
How long is the CPZ protein?
The Homo sapiens CPZ protein (UniProt Q66K79) is 652 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q66K79 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q66K79 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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