Transmembrane protein 42 (TMEM42)
Homo sapiens — UniProt Q69YG0
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 42 (TMEM42) is a protein from Homo sapiens identified by UniProt accession Q69YG0, 159 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q69YG0; gene symbol TMEM42.
- Organism: Homo sapiens.
- Length: 159 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, idiopathic pulmonary fibrosis and dacryocystitis-osteopoikilosis syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 42 |
|---|---|
| UniProt accession | Q69YG0 |
| Gene | TMEM42 |
| Organism | Homo sapiens |
| Length | 159 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.21
- idiopathic pulmonary fibrosis · score 0.15
- dacryocystitis-osteopoikilosis syndrome · score 0.04
- melorheostosis · score 0.04
- autosomal recessive hypophosphatemic rickets · score 0.04
- 12q14 microdeletion syndrome · score 0.04
- particulate matter air pollution measurement · score 0.04
- pyknoachondrogenesis · score 0.04
- osteomesopyknosis · score 0.03
- unipolar depression · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q69YG0-F1 | alphafold | PREDICTED | 72.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q69YG0.
Amino-acid sequence (159 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM42?
The strongest Open Targets associations for TMEM42 are pulse pressure measurement, idiopathic pulmonary fibrosis, dacryocystitis-osteopoikilosis syndrome, melorheostosis and autosomal recessive hypophosphatemic rickets.
How long is the TMEM42 protein?
The Homo sapiens TMEM42 protein (UniProt Q69YG0) is 159 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q69YG0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q69YG0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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