Cytospin-A (SPECC1L)
Homo sapiens — UniProt Q69YQ0
Data last refreshed: (UniProt release unknown)
Key facts
Cytospin-A (SPECC1L) is a protein from Homo sapiens identified by UniProt accession Q69YQ0, 1117 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: Q69YQ0; gene symbol SPECC1L.
- Organism: Homo sapiens.
- Length: 1117 amino acids.
- Top disease associations (Open Targets): Teebi hypertelorism syndrome 1, Hypertelorism, Teebi type and Tessier number 4 facial cleft.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytospin-A |
|---|---|
| UniProt accession | Q69YQ0 |
| Gene | SPECC1L |
| Organism | Homo sapiens |
| Length | 1117 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- Teebi hypertelorism syndrome 1 · score 0.66
- Hypertelorism, Teebi type · score 0.64
- Tessier number 4 facial cleft · score 0.62
- Teebi hypertelorism syndrome · score 0.52
- neurodegenerative disease · score 0.49
- serum gamma-glutamyl transferase measurement · score 0.46
- Intellectual disability · score 0.44
- lateral facial cleft · score 0.37
- oculomaxillofacial dysostosis · score 0.36
- Opitz G/BBB syndrome · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q69YQ0-F1 | alphafold | PREDICTED | 65.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q69YQ0.
Amino-acid sequence (1117 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPECC1L?
The strongest Open Targets associations for SPECC1L are Teebi hypertelorism syndrome 1, Hypertelorism, Teebi type, Tessier number 4 facial cleft, Teebi hypertelorism syndrome and neurodegenerative disease.
How long is the SPECC1L protein?
The Homo sapiens SPECC1L protein (UniProt Q69YQ0) is 1117 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q69YQ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q69YQ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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