Keratin, type I cytoskeletal 39 (KRT39)
Homo sapiens — UniProt Q6A163
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type I cytoskeletal 39 (KRT39) is a protein from Homo sapiens identified by UniProt accession Q6A163, 491 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q6A163; gene symbol KRT39.
- Organism: Homo sapiens.
- Length: 491 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, head and neck squamous cell carcinoma and prostate adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type I cytoskeletal 39 |
|---|---|
| UniProt accession | Q6A163 |
| Gene | KRT39 |
| Organism | Homo sapiens |
| Length | 491 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- prostate adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
- low grade glioma · score 0.11
- sebaceous of Jadassohn nevus · score 0.05
- visceral Leishmaniasis · score 0.02
- leprosy · score 0.01
- Leishmaniasis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6A163-F1 | alphafold | PREDICTED | 74.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6A163.
Amino-acid sequence (491 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT39?
The strongest Open Targets associations for KRT39 are glioblastoma multiforme, head and neck squamous cell carcinoma, prostate adenocarcinoma, breast adenocarcinoma and esophageal cancer.
How long is the KRT39 protein?
The Homo sapiens KRT39 protein (UniProt Q6A163) is 491 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6A163 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6A163 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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