Sodium/hydrogen exchanger 4 (SLC9A4)
Homo sapiens — UniProt Q6AI14
Data last refreshed: (UniProt release unknown)
Key facts
Sodium/hydrogen exchanger 4 (SLC9A4) is a protein from Homo sapiens identified by UniProt accession Q6AI14, 798 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.
- UniProt accession: Q6AI14; gene symbol SLC9A4.
- Organism: Homo sapiens.
- Length: 798 amino acids.
- Top disease associations (Open Targets): Ascending aortic dissection, body height and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium/hydrogen exchanger 4 |
|---|---|
| UniProt accession | Q6AI14 |
| Gene | SLC9A4 |
| Organism | Homo sapiens |
| Length | 798 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- Ascending aortic dissection · score 0.47
- body height · score 0.44
- mean corpuscular hemoglobin concentration · score 0.41
- interleukin 18 receptor 1 measurement · score 0.40
- celiac disease · score 0.38
- appendicular lean mass · score 0.38
- sleep apnea measurement · score 0.36
- ST2 protein measurement · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.33
- interleukin 1 receptor-like 1 measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6AI14-F1 | alphafold | PREDICTED | 66.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6AI14.
Amino-acid sequence (798 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC9A4?
The strongest Open Targets associations for SLC9A4 are Ascending aortic dissection, body height, mean corpuscular hemoglobin concentration, interleukin 18 receptor 1 measurement and celiac disease.
How long is the SLC9A4 protein?
The Homo sapiens SLC9A4 protein (UniProt Q6AI14) is 798 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6AI14 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6AI14 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.