Tigger transposable element-derived protein 3 (TIGD3)
Homo sapiens — UniProt Q6B0B8
Data last refreshed: (UniProt release unknown)
Key facts
Tigger transposable element-derived protein 3 (TIGD3) is a protein from Homo sapiens identified by UniProt accession Q6B0B8, 471 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q6B0B8; gene symbol TIGD3.
- Organism: Homo sapiens.
- Length: 471 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, urate measurement and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tigger transposable element-derived protein 3 |
|---|---|
| UniProt accession | Q6B0B8 |
| Gene | TIGD3 |
| Organism | Homo sapiens |
| Length | 471 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- urate measurement · score 0.12
- mean corpuscular hemoglobin concentration · score 0.07
- open-angle glaucoma · score 0.05
- MODY · score 0.05
- mean corpuscular volume · score 0.05
- hemoglobin A1 measurement · score 0.05
- myeloid white cell count · score 0.05
- diabetes mellitus, permanent neonatal 4 · score 0.04
- body height · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6B0B8-F1 | alphafold | PREDICTED | 79.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6B0B8.
Amino-acid sequence (471 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TIGD3?
The strongest Open Targets associations for TIGD3 are neurodegenerative disease, urate measurement, mean corpuscular hemoglobin concentration, open-angle glaucoma and MODY.
How long is the TIGD3 protein?
The Homo sapiens TIGD3 protein (UniProt Q6B0B8) is 471 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6B0B8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6B0B8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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