Lysine-specific demethylase 4D (KDM4D)
Homo sapiens — UniProt Q6B0I6
Data last refreshed: (UniProt release unknown)
Key facts
Lysine-specific demethylase 4D (KDM4D) is a protein from Homo sapiens identified by UniProt accession Q6B0I6, 523 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q6B0I6; gene symbol KDM4D.
- Organism: Homo sapiens.
- Length: 523 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, adolescent idiopathic scoliosis and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysine-specific demethylase 4D |
|---|---|
| UniProt accession | Q6B0I6 |
| Gene | KDM4D |
| Organism | Homo sapiens |
| Length | 523 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- adolescent idiopathic scoliosis · score 0.27
- breast adenocarcinoma · score 0.22
- gastrointestinal stromal tumor · score 0.08
- esophageal squamous cell carcinoma · score 0.07
- nonpapillary renal cell carcinoma · score 0.07
- azoospermia · score 0.07
- neoplasm · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- Hepatic fibrosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6B0I6-F1 | alphafold | PREDICTED | 73.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6B0I6.
Amino-acid sequence (523 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KDM4D?
The strongest Open Targets associations for KDM4D are neurodegenerative disease, adolescent idiopathic scoliosis, breast adenocarcinoma, gastrointestinal stromal tumor and esophageal squamous cell carcinoma.
How long is the KDM4D protein?
The Homo sapiens KDM4D protein (UniProt Q6B0I6) is 523 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6B0I6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6B0I6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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