N6-Methyl-AMP deaminase (MAPDA)

About N6-Methyl-AMP deaminase

N6-Methyl-AMP deaminase (MAPDA) is a protein from Homo sapiens identified by UniProt accession Q6DHV7, 355 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	N6-Methyl-AMP deaminase
UniProt accession	Q6DHV7
Gene	MAPDA
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

stem Cell Factor measurement · score 0.21
cutaneous melanoma · score 0.13
alcohol dependence · score 0.09
eosinophil count · score 0.07
eosinophil percentage of leukocytes · score 0.07
age at menopause · score 0.06
hip circumference · score 0.06
adolescent idiopathic scoliosis · score 0.05
macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
thrombocytopenia 4 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6DHV7-F1	alphafold	PREDICTED	93.40	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6DHV7.

Amino-acid sequence (355 residues)

MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTVGQAKD FLEPLLEAKK AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE GGSLDLVDFV RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP RVLHI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards