Transmembrane protein PVRIG (PVRIG)
Homo sapiens — UniProt Q6DKI7
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein PVRIG (PVRIG) is a protein from Homo sapiens identified by UniProt accession Q6DKI7, 326 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q6DKI7; gene symbol PVRIG.
- Organism: Homo sapiens.
- Length: 326 amino acids.
- Top disease associations (Open Targets): forced expiratory volume, hemoglobin measurement and age at menopause.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein PVRIG |
|---|---|
| UniProt accession | Q6DKI7 |
| Gene | PVRIG |
| Organism | Homo sapiens |
| Length | 326 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- forced expiratory volume · score 0.16
- hemoglobin measurement · score 0.11
- age at menopause · score 0.11
- neoplasm · score 0.10
- FEV/FVC ratio · score 0.10
- insulin like growth factor measurement · score 0.09
- mean corpuscular volume · score 0.09
- mean corpuscular hemoglobin · score 0.09
- acute myeloid leukemia · score 0.08
- erythrocyte count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6DKI7-F1 | alphafold | PREDICTED | 60.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6DKI7.
Amino-acid sequence (326 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PVRIG?
The strongest Open Targets associations for PVRIG are forced expiratory volume, hemoglobin measurement, age at menopause, neoplasm and FEV/FVC ratio.
How long is the PVRIG protein?
The Homo sapiens PVRIG protein (UniProt Q6DKI7) is 326 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6DKI7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6DKI7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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