Nucleoredoxin (NXN)
Homo sapiens — UniProt Q6DKJ4
Data last refreshed: (UniProt release unknown)
Key facts
Nucleoredoxin (NXN) is a protein from Homo sapiens identified by UniProt accession Q6DKJ4, 435 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.
- UniProt accession: Q6DKJ4; gene symbol NXN.
- Organism: Homo sapiens.
- Length: 435 amino acids.
- Top disease associations (Open Targets): Robinow syndrome, colorectal cancer and colorectal adenoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleoredoxin |
|---|---|
| UniProt accession | Q6DKJ4 |
| Gene | NXN |
| Organism | Homo sapiens |
| Length | 435 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (223)
Diseases linked to this target (Open Targets).
- Robinow syndrome · score 0.60
- colorectal cancer · score 0.45
- colorectal adenoma · score 0.37
- autosomal recessive Robinow syndrome · score 0.37
- refractive error measurement · score 0.31
- polyp of colon · score 0.31
- lymphocyte count · score 0.28
- platelet count · score 0.26
- heel bone mineral density · score 0.23
- neurodegenerative disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6DKJ4-F1 | alphafold | PREDICTED | 89.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6DKJ4.
Amino-acid sequence (435 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NXN?
The strongest Open Targets associations for NXN are Robinow syndrome, colorectal cancer, colorectal adenoma, autosomal recessive Robinow syndrome and refractive error measurement.
How long is the NXN protein?
The Homo sapiens NXN protein (UniProt Q6DKJ4) is 435 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6DKJ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6DKJ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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