Dermokine (DMKN)
Homo sapiens — UniProt Q6E0U4
Data last refreshed: (UniProt release unknown)
Key facts
Dermokine (DMKN) is a protein from Homo sapiens identified by UniProt accession Q6E0U4, 476 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q6E0U4; gene symbol DMKN.
- Organism: Homo sapiens.
- Length: 476 amino acids.
- Top disease associations (Open Targets): melanoma, Miyoshi myopathy and peeling skin syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dermokine |
|---|---|
| UniProt accession | Q6E0U4 |
| Gene | DMKN |
| Organism | Homo sapiens |
| Length | 476 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- melanoma · score 0.08
- Miyoshi myopathy · score 0.08
- peeling skin syndrome · score 0.06
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.06
- erythrokeratodermia variabilis · score 0.06
- platelet count · score 0.06
- epidermolysis bullosa simplex 4, localized or generalized intermediate, autosomal recessive · score 0.06
- Ichthyosis-hypotrichosis syndrome · score 0.06
- acrokeratosis verruciformis · score 0.06
- focal palmoplantar and gingival keratoderma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6E0U4-F1 | alphafold | PREDICTED | 41.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6E0U4.
Amino-acid sequence (476 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DMKN?
The strongest Open Targets associations for DMKN are melanoma, Miyoshi myopathy, peeling skin syndrome, hereditary palmoplantar keratoderma, Gamborg-Nielsen type and erythrokeratodermia variabilis.
How long is the DMKN protein?
The Homo sapiens DMKN protein (UniProt Q6E0U4) is 476 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6E0U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6E0U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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