Acyl-CoA wax alcohol acyltransferase 2 (AWAT2)
Homo sapiens — UniProt Q6E213
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-CoA wax alcohol acyltransferase 2 (AWAT2) is a protein from Homo sapiens identified by UniProt accession Q6E213, 333 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q6E213; gene symbol AWAT2.
- Organism: Homo sapiens.
- Length: 333 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, breast adenocarcinoma and keratosis follicularis spinulosa decalvans.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-CoA wax alcohol acyltransferase 2 |
|---|---|
| UniProt accession | Q6E213 |
| Gene | AWAT2 |
| Organism | Homo sapiens |
| Length | 333 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- keratosis follicularis spinulosa decalvans · score 0.06
- ectodermal dysplasia-blindness syndrome · score 0.05
- Ichthyosis-hypotrichosis syndrome · score 0.05
- Clouston syndrome · score 0.05
- isolated congenital alacrima · score 0.05
- acrodermatitis enteropathica · score 0.05
- Olmsted syndrome 1 · score 0.05
- pili torti-onychodysplasia syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6E213-F1 | alphafold | PREDICTED | 94.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6E213.
Amino-acid sequence (333 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AWAT2?
The strongest Open Targets associations for AWAT2 are glioblastoma multiforme, breast adenocarcinoma, keratosis follicularis spinulosa decalvans, ectodermal dysplasia-blindness syndrome and Ichthyosis-hypotrichosis syndrome.
How long is the AWAT2 protein?
The Homo sapiens AWAT2 protein (UniProt Q6E213) is 333 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6E213 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6E213 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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