General transcription factor II-I repeat domain-containing protein 2B (GTF2IRD2B)
Homo sapiens — UniProt Q6EKJ0
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor II-I repeat domain-containing protein 2B (GTF2IRD2B) is a protein from Homo sapiens identified by UniProt accession Q6EKJ0, 949 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q6EKJ0; gene symbol GTF2IRD2B.
- Organism: Homo sapiens.
- Length: 949 amino acids.
- Top disease associations (Open Targets): blood protein measurement, neutrophil percentage of leukocytes and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor II-I repeat domain-containing protein 2B |
|---|---|
| UniProt accession | Q6EKJ0 |
| Gene | GTF2IRD2B |
| Organism | Homo sapiens |
| Length | 949 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.08
- neutrophil percentage of leukocytes · score 0.03
- hepatocellular carcinoma · score 0.01
- liver and intrahepatic bile duct neoplasm · score 0.00
- supravalvular aortic stenosis · score 0.00
- chronic obstructive pulmonary disease · score 0.00
- Supravalvular aortic stenosis · score 0.00
- pulmonary arterial hypertension · score 0.00
- Williams syndrome · score 0.00
- glycogen storage disease VI · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6EKJ0-F1 | alphafold | PREDICTED | 72.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6EKJ0.
Amino-acid sequence (949 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF2IRD2B?
The strongest Open Targets associations for GTF2IRD2B are blood protein measurement, neutrophil percentage of leukocytes, hepatocellular carcinoma, liver and intrahepatic bile duct neoplasm and supravalvular aortic stenosis.
How long is the GTF2IRD2B protein?
The Homo sapiens GTF2IRD2B protein (UniProt Q6EKJ0) is 949 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6EKJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6EKJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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