Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2)

Homo sapiens — UniProt Q6F5E8

Gene: CARMIL2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2) is a protein from Homo sapiens identified by UniProt accession Q6F5E8, 1435 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.

UniProt accession: Q6F5E8; gene symbol CARMIL2.
Organism: Homo sapiens.
Length: 1435 amino acids.
Top disease associations (Open Targets): severe combined immunodeficiency due to CARMIL2 deficiency, combined immunodeficiency and Combined immunodeficiency.
3D structure: AlphaFold model available.

Target properties

Protein name	Capping protein, Arp2/3 and myosin-I linker protein 2
UniProt accession	Q6F5E8
Gene	CARMIL2
Organism	Homo sapiens
Length	1435 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (122)

Diseases linked to this target (Open Targets).

severe combined immunodeficiency due to CARMIL2 deficiency · score 0.77
combined immunodeficiency · score 0.58
Combined immunodeficiency · score 0.46
Combined T and B cell immunodeficiency · score 0.46
Chronic colitis · score 0.34
lymphocyte count · score 0.33
eosinophil count · score 0.33
total blood protein measurement · score 0.24
eosinophil percentage of leukocytes · score 0.23
leukocyte count · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6F5E8-F1	alphafold	PREDICTED	61.05	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6F5E8.

Amino-acid sequence (1435 residues)

MAQTPDGISC ELRGEITRFL WPKEVELLLK TWLPGEGAVQ NHVLALLRWR AYLLHTTCLP LRVDCTFSYL EVQAMALQET PPQVTFELES LRELVLEFPG VAALEQLAQH VAAAIKKVFP RSTLGKLFRR PTPASMLARL ERSSPSESTD PCSPCGGFLE TYEALCDYNG FPFREEIQWD VDTIYHRQGC RHFSLGDFSH LGSRDLALSV AALSYNLWFR CLSCVDMKLS LEVSEQILHM MSQSSHLEEL VLETCSLRGD FVRRLAQALA GHSSSGLREL SLAGNLLDDR GMTALSRHLE RCPGALRRLS LAQTGLTPRG MRALGRALAT NAAFDSTLTH LDLSGNPGAL GASEDSGGLY SFLSRPNVLS FLNLAGTDTA LDTVRGCSVG GWMTGRADWR AGRGGLGPPA GVANSLPPQL FAAVSRGCCT SLTHLDASRN VFSRTKSRAA PAALQLFLSR ARTLRHLGLA GCKLPPDALR ALLDGLALNT HLRDLHLDLS ACELRSAGAQ VIQDLVCDAG AVSSLDLADN GFGSDMVTLV LAIGRSRSLR HVALGRNFNV RCKETLDDVL HRIVQLMQDD DCPLQSLSVA ESRLKLGASV LLRALATNPN LTALDISGNA MGDAGAKLLA KALRVNSRLR SVVWDRNHTS ALGLLDVAQA LEQNHSLKAM PLPLNDVAQA QRSRPELTAR AVHQIQACLL RNNRADPASS DHTTRLQPLG LVSDPSEQEV NELCQSVQEH VELLGCGAGP QGEAAVRQAE DAIQNANFSL SILPILYEAG SSPSHHWQLG QKLEGLLRQV GEVCRQDIQD FTQATLDTAR SLCPQMLQGS SWREQLEGVL AGSRGLPELL PEQLLQDAFT RLRDMRLSIT GTLAESIVAQ ALAGLSAARD QLVESLAQQA TVTMPPALPA PDGGEPSLLE PGELEGLFFP EEKEEEKEKD DSPPQKWPEL SHGLHLVPFI HSAAEEAEPE PELAAPGEDA EPQAGPSARG SPSPAAPGPP AGPLPRMDLP LAGQPLRHPT RARPRPRRQH HHRPPPGGPQ VPPALPQEGN GLSARVDEGV EEFFSKRLIQ QDRLWAPEED PATEGGATPV PRTLRKKLGT LFAFKKPRST RGPRTDLETS PGAAPRTRKT TFGDLLRPPT RPSRGEELGG AEGDTSSPDP AGRSRPRYTR DSKAYSMILL PAEEEATLGA RPDKRRPLER GETELAPSFE QRVQVMLQRI GVSRGSGGAE GKRKQSKDGE IKKAGSDGDI MDSSTEAPPI SIKSRTHSVS ADPSCRPGPG SQGPESATWK TLGQQLNAEL RSRGWGQQDG PGPPSPGQSP SPCRTSPSPD SLGLPEDPCL GPRNEDGQLR PRPLSAGRRA VSVHEDQLQA PAERPLRLQR SPVLKRRPKL EAPPSPSLGS GLGTEPLPPQ PTEPSSPERS PPSPATDQRG GGPNP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with CARMIL2?

The strongest Open Targets associations for CARMIL2 are severe combined immunodeficiency due to CARMIL2 deficiency, combined immunodeficiency, Combined immunodeficiency, Combined T and B cell immunodeficiency and Chronic colitis.

How long is the CARMIL2 protein?

The Homo sapiens CARMIL2 protein (UniProt Q6F5E8) is 1435 amino acids long.

Browse: Targets: C · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6F5E8 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6F5E8 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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