Secreted frizzled-related protein 4 (SFRP4)
Homo sapiens — UniProt Q6FHJ7
Data last refreshed: (UniProt release unknown)
Key facts
Secreted frizzled-related protein 4 (SFRP4) is a protein from Homo sapiens identified by UniProt accession Q6FHJ7, 346 residues long. MolForge cross-references it against 0 known binders and 372 disease associations.
- UniProt accession: Q6FHJ7; gene symbol SFRP4.
- Organism: Homo sapiens.
- Length: 346 amino acids.
- Top disease associations (Open Targets): Pyle disease, heel bone mineral density and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Secreted frizzled-related protein 4 |
|---|---|
| UniProt accession | Q6FHJ7 |
| Gene | SFRP4 |
| Organism | Homo sapiens |
| Length | 346 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (372)
Diseases linked to this target (Open Targets).
- Pyle disease · score 0.69
- heel bone mineral density · score 0.49
- body height · score 0.47
- Metaphyseal dysplasia · score 0.46
- bone density · score 0.46
- bone quantitative ultrasound measurement · score 0.46
- Dupuytren Contracture · score 0.45
- Palmar Fibromatosis · score 0.43
- primary angle closure glaucoma · score 0.39
- Fasciitis · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6FHJ7-F1 | alphafold | PREDICTED | 78.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6FHJ7.
Amino-acid sequence (346 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFRP4?
The strongest Open Targets associations for SFRP4 are Pyle disease, heel bone mineral density, body height, Metaphyseal dysplasia and bone density.
How long is the SFRP4 protein?
The Homo sapiens SFRP4 protein (UniProt Q6FHJ7) is 346 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6FHJ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6FHJ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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