Protein-lysine N-trimethyltransferase SMYD5 (SMYD5)
Homo sapiens — UniProt Q6GMV2
Data last refreshed: (UniProt release unknown)
Key facts
Protein-lysine N-trimethyltransferase SMYD5 (SMYD5) is a protein from Homo sapiens identified by UniProt accession Q6GMV2, 418 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q6GMV2; gene symbol SMYD5.
- Organism: Homo sapiens.
- Length: 418 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, inflammatory bowel disease and intelligence.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein-lysine N-trimethyltransferase SMYD5 |
|---|---|
| UniProt accession | Q6GMV2 |
| Gene | SMYD5 |
| Organism | Homo sapiens |
| Length | 418 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.09
- inflammatory bowel disease · score 0.08
- intelligence · score 0.05
- mean arterial pressure · score 0.04
- cancer · score 0.03
- cognitive function measurement · score 0.03
- neoplasm · score 0.03
- autosomal recessive hypophosphatemic rickets · score 0.03
- colitis · score 0.03
- hepatocellular carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6GMV2-F1 | alphafold | PREDICTED | 88.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6GMV2.
Amino-acid sequence (418 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMYD5?
The strongest Open Targets associations for SMYD5 are self reported educational attainment, inflammatory bowel disease, intelligence, mean arterial pressure and cancer.
How long is the SMYD5 protein?
The Homo sapiens SMYD5 protein (UniProt Q6GMV2) is 418 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6GMV2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6GMV2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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