Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1)
Homo sapiens — UniProt Q6GPH6
Data last refreshed: (UniProt release unknown)
Key facts
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1) is a protein from Homo sapiens identified by UniProt accession Q6GPH6, 555 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q6GPH6; gene symbol ITPRIPL1.
- Organism: Homo sapiens.
- Length: 555 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, prostate cancer and Familial prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 |
|---|---|
| UniProt accession | Q6GPH6 |
| Gene | ITPRIPL1 |
| Organism | Homo sapiens |
| Length | 555 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- mathematical ability · score 0.10
- neoplasm · score 0.09
- breast cancer · score 0.08
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- non-small cell lung carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6GPH6-F1 | alphafold | PREDICTED | 78.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6GPH6.
Amino-acid sequence (555 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ITPRIPL1?
The strongest Open Targets associations for ITPRIPL1 are neurodegenerative disease, prostate cancer, Familial prostate cancer, prostate carcinoma and mathematical ability.
How long is the ITPRIPL1 protein?
The Homo sapiens ITPRIPL1 protein (UniProt Q6GPH6) is 555 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6GPH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6GPH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.