Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)
Homo sapiens — UniProt Q6GTX8
Data last refreshed: (UniProt release unknown)
Key facts
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a protein from Homo sapiens identified by UniProt accession Q6GTX8, 287 residues long. MolForge cross-references it against 0 known binders and 307 disease associations.
- UniProt accession: Q6GTX8; gene symbol LAIR1.
- Organism: Homo sapiens.
- Length: 287 amino acids.
- Top disease associations (Open Targets): inflammatory bowel disease, neoplasm and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leukocyte-associated immunoglobulin-like receptor 1 |
|---|---|
| UniProt accession | Q6GTX8 |
| Gene | LAIR1 |
| Organism | Homo sapiens |
| Length | 287 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (307)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.16
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- acute myeloid leukemia · score 0.10
- Systemic lupus erythematosus · score 0.09
- severe malarial anemia · score 0.09
- Rheumatoid arthritis · score 0.09
- osteosarcoma · score 0.08
- acute lymphoblastic leukemia · score 0.08
- chronic hepatitis B virus infection · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6GTX8-F1 | alphafold | PREDICTED | 71.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6GTX8.
Amino-acid sequence (287 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LAIR1?
The strongest Open Targets associations for LAIR1 are inflammatory bowel disease, neoplasm, hepatocellular carcinoma, acute myeloid leukemia and Systemic lupus erythematosus.
How long is the LAIR1 protein?
The Homo sapiens LAIR1 protein (UniProt Q6GTX8) is 287 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6GTX8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6GTX8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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