Transmembrane protein 225 (TMEM225)
Homo sapiens — UniProt Q6GV28
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 225 (TMEM225) is a protein from Homo sapiens identified by UniProt accession Q6GV28, 225 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q6GV28; gene symbol TMEM225.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): non-small cell lung carcinoma, bone density and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 225 |
|---|---|
| UniProt accession | Q6GV28 |
| Gene | TMEM225 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.03
- bone density · score 0.03
- urate measurement · score 0.03
- Reduced sperm motility · score 0.02
- Infertility · score 0.01
- Abnormal sperm morphology · score 0.01
- urinary bladder carcinoma · score 0.01
- Azoospermia · score 0.01
- neoplasm · score 0.00
- Undifferentiated Pancreatic Carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6GV28-F1 | alphafold | PREDICTED | 75.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6GV28.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM225?
The strongest Open Targets associations for TMEM225 are non-small cell lung carcinoma, bone density, urate measurement, Reduced sperm motility and Infertility.
How long is the TMEM225 protein?
The Homo sapiens TMEM225 protein (UniProt Q6GV28) is 225 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6GV28 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6GV28 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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