About Isthmin-2
Isthmin-2 (ISM2) is a protein
from Homo sapiens identified by UniProt accession
Q6H9L7, 571 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (26)
Diseases linked to this target (Open Targets).
- neutrophil percentage of leukocytes · score 0.24
- lymphocyte percentage of leukocytes · score 0.12
- neutrophil count · score 0.10
- leukocyte count · score 0.07
- sum of neutrophil and eosinophil counts · score 0.07
- sum of basophil and neutrophil counts · score 0.07
- granulocyte count · score 0.06
- protein measurement · score 0.06
- myeloid white cell count · score 0.06
- preeclampsia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q6H9L7.
Amino-acid sequence (571 residues)
MRALRDRAGL LLCVLLLAAL LEAALGLPVK KPRLRGPRPG SLTRLAEVSA SPDPRPLKEE EEAPLLPRTH LQAEPHQHGC WTVTEPAAMT PGNATPPRTP EVTPLRLELQ KLPGLANTTL STPNPDTQAS ASPDPRPLRE EEEARLLPRT HLQAELHQHG CWTVTEPAAL TPGNATPPRT QEVTPLLLEL QKLPELVHAT LSTPNPDNQV TIKVVEDPQA EVSIDLLAEP SNPPPQDTLS WLPALWSFLW GDYKGEEKDR APGEKGEEKE EDEDYPSEDI EGEDQEDKEE DEEEQALWFN GTTDNWDQGW LAPGDWVFKD SVSYDYEPQK EWSPWSPCSG NCSTGKQQRT RPCGYGCTAT ETRTCDLPSC PGTEDKDTLG LPSEEWKLLA RNATDMHDQD VDSCEKWLNC KSDFLIKYLS QMLRDLPSCP CAYPLEAMDS PVSLQDEHQG RSFRWRDASG PRERLDIYQP TARFCLRSML SGESSTLAAQ HCCYDEDSRL LTRGKGAGMP NLISTDFSPK LHFKFDTTPW ILCKGDWSRL HAVLPPNNGR ACTDNPLEEE YLAQLQEAKE Y
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