Twinfilin-2 (TWF2)
Homo sapiens — UniProt Q6IBS0
Data last refreshed: (UniProt release unknown)
Key facts
Twinfilin-2 (TWF2) is a protein from Homo sapiens identified by UniProt accession Q6IBS0, 349 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q6IBS0; gene symbol TWF2.
- Organism: Homo sapiens.
- Length: 349 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Twinfilin-2 |
|---|---|
| UniProt accession | Q6IBS0 |
| Gene | TWF2 |
| Organism | Homo sapiens |
| Length | 349 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.20
- platelet count · score 0.11
- BMI-adjusted waist-hip ratio · score 0.09
- blood protein measurement · score 0.08
- schizophrenia · score 0.08
- bipolar disorder · score 0.08
- neoplasm · score 0.08
- glomerular filtration rate · score 0.08
- creatinine measurement · score 0.07
- body mass index · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6IBS0-F1 | alphafold | PREDICTED | 91.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6IBS0.
Amino-acid sequence (349 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TWF2?
The strongest Open Targets associations for TWF2 are neurodegenerative disease, platelet count, BMI-adjusted waist-hip ratio, blood protein measurement and schizophrenia.
How long is the TWF2 protein?
The Homo sapiens TWF2 protein (UniProt Q6IBS0) is 349 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6IBS0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6IBS0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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