Postacrosomal sheath WW domain-binding protein…

About Postacrosomal sheath WW domain-binding protein

Postacrosomal sheath WW domain-binding protein (WBP2NL) is a protein from Homo sapiens identified by UniProt accession Q6ICG8, 309 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Postacrosomal sheath WW domain-binding protein
UniProt accession	Q6ICG8
Gene	WBP2NL
Organism	Homo sapiens
Length	309 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.24
unipolar depression · score 0.20
leukocyte count · score 0.20
calcium measurement · score 0.19
cognitive function measurement · score 0.19
self reported educational attainment · score 0.18
response to selective serotonin reuptake inhibitor · score 0.17
autism spectrum disorder · score 0.17
bipolar disorder · score 0.16
intelligence · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6ICG8-F1	alphafold	PREDICTED	62.36	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ICG8.

Amino-acid sequence (309 residues)

MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT LFLTSYRVIF ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ AAPYGGWEGQ ATFKLVFRNG DAIEFAQLMV KAASAAARGF PLRTLNDWFS SMGIYVITGE GNMCTPQMPC SVIVYGAPPA GYGAPPPGYG APPAGYGAQP VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA PPLGYGTPPL GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP SASSSQVHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Postacrosomal sheath WW domain-binding protein (WBP2NL)