Serine protease inhibitor Kazal-type 14 (SPINK14)
Homo sapiens — UniProt Q6IE38
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease inhibitor Kazal-type 14 (SPINK14) is a protein from Homo sapiens identified by UniProt accession Q6IE38, 97 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q6IE38; gene symbol SPINK14.
- Organism: Homo sapiens.
- Length: 97 amino acids.
- Top disease associations (Open Targets): blood protein measurement, immunodeficiency 19 and monocytopenia with susceptibility to infections.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease inhibitor Kazal-type 14 |
|---|---|
| UniProt accession | Q6IE38 |
| Gene | SPINK14 |
| Organism | Homo sapiens |
| Length | 97 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.12
- immunodeficiency 19 · score 0.04
- monocytopenia with susceptibility to infections · score 0.04
- agammaglobulinemia 7, autosomal recessive · score 0.04
- ghosal hematodiaphyseal dysplasia · score 0.04
- combined immunodeficiency due to partial RAG1 deficiency · score 0.04
- immunodeficiency 18 · score 0.04
- inborn error of immunity · score 0.04
- severe combined immunodeficiency due to IKK2 deficiency · score 0.04
- X-Linked Combined Immunodeficiency Diseases · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6IE38-F1 | alphafold | PREDICTED | 81.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6IE38.
Amino-acid sequence (97 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINK14?
The strongest Open Targets associations for SPINK14 are blood protein measurement, immunodeficiency 19, monocytopenia with susceptibility to infections, agammaglobulinemia 7, autosomal recessive and ghosal hematodiaphyseal dysplasia.
How long is the SPINK14 protein?
The Homo sapiens SPINK14 protein (UniProt Q6IE38) is 97 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6IE38 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6IE38 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.