Speckle-type POZ protein-like (SPOPL)
Homo sapiens — UniProt Q6IQ16
Data last refreshed: (UniProt release unknown)
Key facts
Speckle-type POZ protein-like (SPOPL) is a protein from Homo sapiens identified by UniProt accession Q6IQ16, 392 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q6IQ16; gene symbol SPOPL.
- Organism: Homo sapiens.
- Length: 392 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, sleep duration and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Speckle-type POZ protein-like |
|---|---|
| UniProt accession | Q6IQ16 |
| Gene | SPOPL |
| Organism | Homo sapiens |
| Length | 392 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- sleep duration · score 0.24
- multiple sclerosis · score 0.19
- autosomal recessive spondylocostal dysostosis · score 0.07
- cervical spondylosis · score 0.05
- Prata-Liberal-Goncalves syndrome · score 0.04
- osteomesopyknosis · score 0.04
- pregnancy induced alloimmunization · score 0.04
- PHF-tau measurement · score 0.04
- primary basilar invagination · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6IQ16-F1 | alphafold | PREDICTED | 86.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6IQ16.
Amino-acid sequence (392 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPOPL?
The strongest Open Targets associations for SPOPL are neurodegenerative disease, sleep duration, multiple sclerosis, autosomal recessive spondylocostal dysostosis and cervical spondylosis.
How long is the SPOPL protein?
The Homo sapiens SPOPL protein (UniProt Q6IQ16) is 392 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6IQ16 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6IQ16 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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