About N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) is a protein
from Homo sapiens identified by UniProt accession
Q6IQ20, 393 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D |
|---|
| UniProt accession | Q6IQ20 |
|---|
| Gene | NAPEPLD |
|---|
| Organism | Homo sapiens |
|---|
| Length | 393 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (57)
Diseases linked to this target (Open Targets).
- reticular dystrophy of the retinal pigment epithelium · score 0.37
- type 2 diabetes mellitus · score 0.24
- chronotype measurement · score 0.13
- bone density · score 0.06
- urate measurement · score 0.06
- lower face morphology measurement · score 0.03
- diabetes mellitus · score 0.02
- neoplasm · score 0.02
- Obesity · score 0.02
- brain measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6IQ20-F1 | alphafold | PREDICTED | 87.28 | — |
Amino-acid sequence (393 residues)
MDENESNQSL MTSSQYPKEA VRKRQNSARN SGASDSSRFS RKSFKLDYRL EEDVTKSKKG KDGRFVNPWP TWKNPSIPNV LRWLIMEKDH SSVPSSKEEL DKELPVLKPY FITNPEEAGV REAGLRVTWL GHATVMVEMD ELIFLTDPIF SSRASPSQYM GPKRFRRSPC TISELPPIDA VLISHNHYDH LDYNSVIALN ERFGNELRWF VPLGLLDWMQ KCGCENVIEL DWWEENCVPG HDKVTFVFTP SQHWCKRTLM DDNKVLWGSW SVLGPWNRFF FAGDTGYCPA FEEIGKRFGP FDLAAIPIGA YEPRWFMKYQ HVDPEEAVRI HTDVQTKKSM AIHWGTFALA NEHYLEPPVK LNEALERYGL NAEDFFVLKH GESRYLNNDD ENF
Explore N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets