Pre T-cell antigen receptor alpha (PTCRA)
Homo sapiens — UniProt Q6ISU1
Data last refreshed: (UniProt release unknown)
Key facts
Pre T-cell antigen receptor alpha (PTCRA) is a protein from Homo sapiens identified by UniProt accession Q6ISU1, 281 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q6ISU1; gene symbol PTCRA.
- Organism: Homo sapiens.
- Length: 281 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Lymphopenia and Autoimmunity.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pre T-cell antigen receptor alpha |
|---|---|
| UniProt accession | Q6ISU1 |
| Gene | PTCRA |
| Organism | Homo sapiens |
| Length | 281 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- Lymphopenia · score 0.18
- Autoimmunity · score 0.18
- lymphopenia · score 0.18
- mean platelet volume · score 0.16
- attention deficit hyperactivity disorder · score 0.12
- antisocial behaviour measurement · score 0.12
- substance abuse · score 0.12
- smoking status measurement · score 0.12
- mediator of RNA polymerase II transcription subunit 1 measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6ISU1-F1 | alphafold | PREDICTED | 63.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6ISU1.
Amino-acid sequence (281 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTCRA?
The strongest Open Targets associations for PTCRA are neurodegenerative disease, Lymphopenia, Autoimmunity, lymphopenia and mean platelet volume.
How long is the PTCRA protein?
The Homo sapiens PTCRA protein (UniProt Q6ISU1) is 281 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6ISU1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6ISU1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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