Mitochondrial sodium/calcium exchanger protein (SLC8B1)
Homo sapiens — UniProt Q6J4K2
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial sodium/calcium exchanger protein (SLC8B1) is a protein from Homo sapiens identified by UniProt accession Q6J4K2, 584 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q6J4K2; gene symbol SLC8B1.
- Organism: Homo sapiens.
- Length: 584 amino acids.
- Top disease associations (Open Targets): neoplasm, colorectal carcinoma and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial sodium/calcium exchanger protein |
|---|---|
| UniProt accession | Q6J4K2 |
| Gene | SLC8B1 |
| Organism | Homo sapiens |
| Length | 584 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.08
- colorectal carcinoma · score 0.07
- blood protein measurement · score 0.06
- body mass index · score 0.05
- response to fenofibrate · score 0.04
- infection · score 0.03
- infect · score 0.03
- cancer · score 0.03
- myeloid sarcoma · score 0.03
- Mental deterioration · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6J4K2-F1 | alphafold | PREDICTED | 80.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6J4K2.
Amino-acid sequence (584 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC8B1?
The strongest Open Targets associations for SLC8B1 are neoplasm, colorectal carcinoma, blood protein measurement, body mass index and response to fenofibrate.
How long is the SLC8B1 protein?
The Homo sapiens SLC8B1 protein (UniProt Q6J4K2) is 584 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6J4K2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6J4K2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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