Epididymal-specific lipocalin-12 (LCN12)

About Epididymal-specific lipocalin-12

Epididymal-specific lipocalin-12 (LCN12) is a protein from Homo sapiens identified by UniProt accession Q6JVE5, 192 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Epididymal-specific lipocalin-12
UniProt accession	Q6JVE5
Gene	LCN12
Organism	Homo sapiens
Length	192 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.15
cutaneous melanoma · score 0.15
central corneal thickness · score 0.10
intraocular pressure measurement · score 0.08
keratoconus · score 0.06
corneal topography · score 0.06
hemoglobin measurement · score 0.04
renal system measurement · score 0.03
platelet crit · score 0.02
platelet count · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6JVE5-F1	alphafold	PREDICTED	86.38	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6JVE5.

Amino-acid sequence (192 residues)

MRLLCGLWLW LSLLKVLQAQ TPTPLPLPPP MQSFQGNQFQ GEWFVLGLAG NSFRPEHRAL LNAFTATFEL SDDGRFEVWN AMTRGQHCDT WSYVLIPAAQ PGQFTVDHGV EPGADREETR VVDSDYTQFA LMLSRRHTSR LAVLRISLLG RSWLLPPGTL DQFICLGRAQ GLSDDNIVFP DVTGWSPQAS VC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards