Epididymal-specific lipocalin-8 (LCN8)
Homo sapiens — UniProt Q6JVE9
Data last refreshed: (UniProt release unknown)
Key facts
Epididymal-specific lipocalin-8 (LCN8) is a protein from Homo sapiens identified by UniProt accession Q6JVE9, 175 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q6JVE9; gene symbol LCN8.
- Organism: Homo sapiens.
- Length: 175 amino acids.
- Top disease associations (Open Targets): cystatin C measurement, creatinine measurement and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epididymal-specific lipocalin-8 |
|---|---|
| UniProt accession | Q6JVE9 |
| Gene | LCN8 |
| Organism | Homo sapiens |
| Length | 175 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- cystatin C measurement · score 0.18
- creatinine measurement · score 0.14
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 49 · score 0.07
- spermatogenic failure 45 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6JVE9-F1 | alphafold | PREDICTED | 79.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6JVE9.
Amino-acid sequence (175 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LCN8?
The strongest Open Targets associations for LCN8 are cystatin C measurement, creatinine measurement, azoospermia, male infertility with teratozoospermia due to single gene mutation and spermatogenic failure 72.
How long is the LCN8 protein?
The Homo sapiens LCN8 protein (UniProt Q6JVE9) is 175 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6JVE9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6JVE9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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