Keratin-associated protein 5-6 (KRTAP5-6)
Homo sapiens — UniProt Q6L8G9
Data last refreshed: (UniProt release unknown)
Key facts
Keratin-associated protein 5-6 (KRTAP5-6) is a protein from Homo sapiens identified by UniProt accession Q6L8G9, 129 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q6L8G9; gene symbol KRTAP5-6.
- Organism: Homo sapiens.
- Length: 129 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, hypertension and brain volume measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin-associated protein 5-6 |
|---|---|
| UniProt accession | Q6L8G9 |
| Gene | KRTAP5-6 |
| Organism | Homo sapiens |
| Length | 129 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.15
- hypertension · score 0.14
- brain volume measurement · score 0.13
- hematocrit · score 0.13
- hemoglobin measurement · score 0.13
- erythrocyte count · score 0.11
- blood protein measurement · score 0.10
- creatinine measurement · score 0.10
- cathepsin D measurement · score 0.07
- Abnormality of refraction · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6L8G9-F1 | alphafold | PREDICTED | 46.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6L8G9.
Amino-acid sequence (129 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRTAP5-6?
The strongest Open Targets associations for KRTAP5-6 are type 2 diabetes mellitus, hypertension, brain volume measurement, hematocrit and hemoglobin measurement.
How long is the KRTAP5-6 protein?
The Homo sapiens KRTAP5-6 protein (UniProt Q6L8G9) is 129 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6L8G9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6L8G9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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