Keratin-associated protein 5-3 (KRTAP5-3)
Homo sapiens — UniProt Q6L8H2
Data last refreshed: (UniProt release unknown)
Key facts
Keratin-associated protein 5-3 (KRTAP5-3) is a protein from Homo sapiens identified by UniProt accession Q6L8H2, 238 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q6L8H2; gene symbol KRTAP5-3.
- Organism: Homo sapiens.
- Length: 238 amino acids.
- Top disease associations (Open Targets): head and neck squamous cell carcinoma, glioblastoma multiforme and clear cell renal carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin-associated protein 5-3 |
|---|---|
| UniProt accession | Q6L8H2 |
| Gene | KRTAP5-3 |
| Organism | Homo sapiens |
| Length | 238 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.18
- glioblastoma multiforme · score 0.18
- clear cell renal carcinoma · score 0.18
- ovarian cancer · score 0.18
- prostate adenocarcinoma · score 0.18
- thyroid gland adenocarcinoma · score 0.16
- body height · score 0.11
- low grade glioma · score 0.11
- brain volume measurement · score 0.10
- neuroimaging measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6L8H2-F1 | alphafold | PREDICTED | 35.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6L8H2.
Amino-acid sequence (238 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRTAP5-3?
The strongest Open Targets associations for KRTAP5-3 are head and neck squamous cell carcinoma, glioblastoma multiforme, clear cell renal carcinoma, ovarian cancer and prostate adenocarcinoma.
How long is the KRTAP5-3 protein?
The Homo sapiens KRTAP5-3 protein (UniProt Q6L8H2) is 238 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6L8H2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6L8H2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.