2',5'-phosphodiesterase 12 (PDE12)
Homo sapiens — UniProt Q6L8Q7
Data last refreshed: (UniProt release unknown)
Key facts
2',5'-phosphodiesterase 12 (PDE12) is a protein from Homo sapiens identified by UniProt accession Q6L8Q7, 609 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q6L8Q7; gene symbol PDE12.
- Organism: Homo sapiens.
- Length: 609 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2',5'-phosphodiesterase 12 |
|---|---|
| UniProt accession | Q6L8Q7 |
| Gene | PDE12 |
| Organism | Homo sapiens |
| Length | 609 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- blood protein measurement · score 0.09
- diastolic blood pressure · score 0.06
- leukocyte count · score 0.05
- type 1 diabetes mellitus · score 0.04
- forced expiratory volume · score 0.04
- body weight · score 0.04
- heel bone mineral density · score 0.03
- monocyte percentage of leukocytes · score 0.02
- anxiety · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6L8Q7-F1 | alphafold | PREDICTED | 89.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6L8Q7.
Amino-acid sequence (609 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDE12?
The strongest Open Targets associations for PDE12 are neurodegenerative disease, blood protein measurement, diastolic blood pressure, leukocyte count and type 1 diabetes mellitus.
How long is the PDE12 protein?
The Homo sapiens PDE12 protein (UniProt Q6L8Q7) is 609 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6L8Q7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6L8Q7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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