Ferroxidase HEPHL1 (HEPHL1)
Homo sapiens — UniProt Q6MZM0
Data last refreshed: (UniProt release unknown)
Key facts
Ferroxidase HEPHL1 (HEPHL1) is a protein from Homo sapiens identified by UniProt accession Q6MZM0, 1159 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.
- UniProt accession: Q6MZM0; gene symbol HEPHL1.
- Organism: Homo sapiens.
- Length: 1159 amino acids.
- Top disease associations (Open Targets): pili torti-developmental delay-neurological abnormalities syndrome, Pili torti - developmental delay - neurological abnormalities and serum alanine aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ferroxidase HEPHL1 |
|---|---|
| UniProt accession | Q6MZM0 |
| Gene | HEPHL1 |
| Organism | Homo sapiens |
| Length | 1159 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (132)
Diseases linked to this target (Open Targets).
- pili torti-developmental delay-neurological abnormalities syndrome · score 0.58
- Pili torti - developmental delay - neurological abnormalities · score 0.58
- serum alanine aminotransferase measurement · score 0.31
- aspartate aminotransferase measurement · score 0.28
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.26
- response to selective serotonin reuptake inhibitor · score 0.15
- lichen planopilaris · score 0.11
- metabolite measurement · score 0.09
- uncombable hair syndrome · score 0.08
- hypotrichosis simplex · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6MZM0-F1 | alphafold | PREDICTED | 89.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6MZM0.
Amino-acid sequence (1159 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HEPHL1?
The strongest Open Targets associations for HEPHL1 are pili torti-developmental delay-neurological abnormalities syndrome, Pili torti - developmental delay - neurological abnormalities, serum alanine aminotransferase measurement, aspartate aminotransferase measurement and aspartate aminotransferase to alanine aminotransferase ratio.
How long is the HEPHL1 protein?
The Homo sapiens HEPHL1 protein (UniProt Q6MZM0) is 1159 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6MZM0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6MZM0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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