Proline-rich protein 27 (PRR27)

About Proline-rich protein 27

Proline-rich protein 27 (PRR27) is a protein from Homo sapiens identified by UniProt accession Q6MZM9, 219 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.

Target properties

Protein name	Proline-rich protein 27
UniProt accession	Q6MZM9
Gene	PRR27
Organism	Homo sapiens
Length	219 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (5)

Diseases linked to this target (Open Targets).

neurodermatitis · score 0.05
prurigo · score 0.05
pulse pressure measurement · score 0.02
breast carcinoma · score 0.01
keratoconus · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6MZM9-F1	alphafold	PREDICTED	54.23	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6MZM9.

Amino-acid sequence (219 residues)

MKLLLWACIV CVAFARKRRF PFIGEDDNDD GHPLHPSLNI PYGIRNLPPP LYYRPVNTVP SYPGNTYTDT GLPSYPWILT SPGFPYVYHI RGFPLATQLN VPPLPPRGFP FVPPSRFFSA AAAPAAPPIA AEPAAAAPLT ATPVAAEPAA GAPVAAEPAA EAPVGAEPAA EAPVAAEPAA EAPVGVEPAA EEPSPAEPAT AKPAAPEPHP SPSLEQANQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards