Proline-rich protein 5-like (PRR5L)

About Proline-rich protein 5-like

Proline-rich protein 5-like (PRR5L) is a protein from Homo sapiens identified by UniProt accession Q6MZQ0, 368 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Proline-rich protein 5-like
UniProt accession	Q6MZQ0
Gene	PRR5L
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

asthma · score 0.51
Eczematoid dermatitis · score 0.50
BMI-adjusted waist-hip ratio · score 0.47
atopic eczema · score 0.46
mean corpuscular volume · score 0.45
skin disease · score 0.44
erythrocyte count · score 0.44
waist-hip ratio · score 0.43
childhood onset asthma · score 0.42
mean corpuscular hemoglobin · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6MZQ0-F1	alphafold	PREDICTED	67.76	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6MZQ0.

Amino-acid sequence (368 residues)

MTRGFAPILP VEFHKMGSFR RPRPRFMSSP VLSDLPRFQA ARQALQLSSS SAWNSVQTAV INVFKGGGLQ SNELYALNEN IRRLLKSELG SFITDYFQNQ LLAKGLFFVE EKIKLCEGEN RIEVLAEVWD HFFTETLPTL QAIFYPVQGQ ELTIRQISLL GFRDLVLLKV KLGDLLLLAQ SKLPSSIVQM LLILQSVHEP TGPSESYLQL EELVKQVVSP FLGISGDRSF SGPTYTLARR HSRVRPKVTV LNYASPITAV SRPLNEMVLT PLTEQEGEAY LEKCGSVRRH TVANAHSDIQ LLAMATMMHS GLGEEASSEN KCLLLPPSFP PPHRQCSSEP NITDNPDGLE EGARGSQEGS ELNCASLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards