About Teneurin-4
Teneurin-4 (TENM4) is a protein
from Homo sapiens identified by UniProt accession
Q6N022, 2769 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (111)
Diseases linked to this target (Open Targets).
- essential tremor · score 0.70
- bipolar disorder · score 0.51
- self reported educational attainment · score 0.46
- PHF-tau measurement · score 0.44
- serum gamma-glutamyl transferase measurement · score 0.42
- schizophrenia · score 0.42
- unipolar depression · score 0.42
- diet measurement · score 0.39
- DNA methylation · score 0.36
- mathematical ability · score 0.34
3D Structure (8)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q6N022.
Amino-acid sequence (2769 residues)
MDVKERKPYR SLTRRRDAER RYTSSSADSE EGKAPQKSYS SSETLKAYDQ DARLAYGSRV KDIVPQEAEE FCRTGANFTL RELGLEEVTP PHGTLYRTDI GLPHCGYSMG AGSDADMEAD TVLSPEHPVR LWGRSTRSGR SSCLSSRANS NLTLTDTEHE NTETDHPGGL QNHARLRTPP PPLSHAHTPN QHHAASINSL NRGNFTPRSN PSPAPTDHSL SGEPPAGGAQ EPAHAQENWL LNSNIPLETR NLGKQPFLGT LQDNLIEMDI LGASRHDGAY SDGHFLFKPG GTSPLFCTTS PGYPLTSSTV YSPPPRPLPR STFARPAFNL KKPSKYCNWK CAALSAIVIS ATLVILLAYF VAMHLFGLNW HLQPMEGQMY EITEDTASSW PVPTDVSLYP SGGTGLETPD RKGKGTTEGK PSSFFPEDSF IDSGEIDVGR RASQKIPPGT FWRSQVFIDH PVHLKFNVSL GKAALVGIYG RKGLPPSHTQ FDFVELLDGR RLLTQEARSL EGTPRQSRGT VPPSSHETGF IQYLDSGIWH LAFYNDGKES EVVSFLTTAI ESVDNCPSNC YGNGDCISGT CHCFLGFLGP DCGRASCPVL CSGNGQYMKG RCLCHSGWKG AECDVPTNQC IDVACSNHGT CITGTCICNP GYKGESCEEV DCMDPTCSGR GVCVRGECHC SVGWGGTNCE TPRATCLDQC SGHGTFLPDT GLCSCDPSWT GHDCSIEICA ADCGGHGVCV GGTCRCEDGW MGAACDQRAC HPRCAEHGTC RDGKCECSPG WNGEHCTIAH YLDRVVKEGC PGLCNGNGRC TLDLNGWHCV CQLGWRGAGC DTSMETACGD SKDNDGDGLV DCMDPDCCLQ PLCHINPLCL GSPNPLDIIQ ETQVPVSQQN LHSFYDRIKF LVGRDSTHII PGENPFDGGH ACVIRGQVMT SDGTPLVGVN ISFVNNPLFG YTISRQDGSF DLVTNGGISI ILRFERAPFI TQEHTLWLPW DRFFVMETII MRHEENEIPS CDLSNFARPN PVVSPSPLTS FASSCAEKGP IVPEIQALQE EISISGCKMR LSYLSSRTPG YKSVLRISLT HPTIPFNLMK VHLMVAVEGR LFRKWFAAAP DLSYYFIWDK TDVYNQKVFG LSEAFVSVGY EYESCPDLIL WEKRTTVLQG YEIDASKLGG WSLDKHHALN IQSGILHKGN GENQFVSQQP PVIGSIMGNG RRRSISCPSC NGLADGNKLL APVALTCGSD GSLYVGDFNY IRRIFPSGNV TNILELRNKD FRHSHSPAHK YYLATDPMSG AVFLSDSNSR RVFKIKSTVV VKDLVKNSEV VAGTGDQCLP FDDTRCGDGG KATEATLTNP RGITVDKFGL IYFVDGTMIR RIDQNGIIST LLGSNDLTSA RPLSCDSVMD ISQVHLEWPT DLAINPMDNS LYVLDNNVVL QISENHQVRI VAGRPMHCQV PGIDHFLLSK VAIHATLESA TALAVSHNGV LYIAETDEKK INRIRQVTTS GEISLVAGAP SGCDCKNDAN CDCFSGDDGY AKDAKLNTPS SLAVCADGEL YVADLGNIRI RFIRKNKPFL NTQNMYELSS PIDQELYLFD TTGKHLYTQS LPTGDYLYNF TYTGDGDITL ITDNNGNMVN VRRDSTGMPL WLVVPDGQVY WVTMGTNSAL KSVTTQGHEL AMMTYHGNSG LLATKSNENG WTTFYEYDSF GRLTNVTFPT GQVSSFRSDT DSSVHVQVET SSKDDVTITT NLSASGAFYT LLQDQVRNSY YIGADGSLRL LLANGMEVAL QTEPHLLAGT VNPTVGKRNV TLPIDNGLNL VEWRQRKEQA RGQVTVFGRR LRVHNRNLLS LDFDRVTRTE KIYDDHRKFT LRILYDQAGR PSLWSPSSRL NGVNVTYSPG GYIAGIQRGI MSERMEYDQA GRITSRIFAD GKTWSYTYLE KSMVLLLHSQ RQYIFEFDKN DRLSSVTMPN VARQTLETIR SVGYYRNIYQ PPEGNASVIQ DFTEDGHLLH TFYLGTGRRV IYKYGKLSKL AETLYDTTKV SFTYDETAGM LKTINLQNEG FTCTIRYRQI GPLIDRQIFR FTEEGMVNAR FDYNYDNSFR VTSMQAVINE TPLPIDLYRY DDVSGKTEQF GKFGVIYYDI NQIITTAVMT HTKHFDAYGR MKEVQYEIFR SLMYWMTVQY DNMGRVVKKE LKVGPYANTT RYSYEYDADG QLQTVSINDK PLWRYSYDLN GNLHLLSPGN SARLTPLRYD IRDRITRLGD VQYKMDEDGF LRQRGGDIFE YNSAGLLIKA YNRAGSWSVR YRYDGLGRRV SSKSSHSHHL QFFYADLTNP TKVTHLYNHS SSEITSLYYD LQGHLFAMEL SSGDEFYIAC DNIGTPLAVF SGTGLMIKQI LYTAYGEIYM DTNPNFQIII GYHGGLYDPL TKLVHMGRRD YDVLAGRWTS PDHELWKHLS SSNVMPFNLY MFKNNNPISN SQDIKCFMTD VNSWLLTFGF QLHNVIPGYP KPDMDAMEPS YELIHTQMKT QEWDNSKSIL GVQCEVQKQL KAFVTLERFD QLYGSTITSC QQAPKTKKFA SSGSVFGKGV KFALKDGRVT TDIISVANED GRRVAAILNH AHYLENLHFT IDGVDTHYFV KPGPSEGDLA ILGLSGGRRT LENGVNVTVS QINTVLNGRT RRYTDIQLQY GALCLNTRYG TTLDEEKARV LELARQRAVR QAWAREQQRL REGEEGLRAW TEGEKQQVLS TGRVQGYDGF FVISVEQYPE LSDSANNIHF MRQSEMGRR
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