DNA oxidative demethylase ALKBH2 (ALKBH2)
Homo sapiens — UniProt Q6NS38
Data last refreshed: (UniProt release unknown)
Key facts
DNA oxidative demethylase ALKBH2 (ALKBH2) is a protein from Homo sapiens identified by UniProt accession Q6NS38, 261 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q6NS38; gene symbol ALKBH2.
- Organism: Homo sapiens.
- Length: 261 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, mitochondrial DNA measurement and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA oxidative demethylase ALKBH2 |
|---|---|
| UniProt accession | Q6NS38 |
| Gene | ALKBH2 |
| Organism | Homo sapiens |
| Length | 261 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.18
- mitochondrial DNA measurement · score 0.11
- platelet count · score 0.10
- platelet-to-lymphocyte ratio · score 0.09
- colorectal carcinoma · score 0.07
- FRAXF syndrome · score 0.05
- metabolite measurement · score 0.04
- cystatin C measurement · score 0.04
- glioblastoma multiforme · score 0.03
- lung adenocarcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NS38-F1 | alphafold | PREDICTED | 83.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NS38.
Amino-acid sequence (261 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALKBH2?
The strongest Open Targets associations for ALKBH2 are breast adenocarcinoma, mitochondrial DNA measurement, platelet count, platelet-to-lymphocyte ratio and colorectal carcinoma.
How long is the ALKBH2 protein?
The Homo sapiens ALKBH2 protein (UniProt Q6NS38) is 261 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NS38 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NS38 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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