Protein FAM53A (FAM53A)
Homo sapiens — UniProt Q6NSI3
Data last refreshed: (UniProt release unknown)
Key facts
Protein FAM53A (FAM53A) is a protein from Homo sapiens identified by UniProt accession Q6NSI3, 398 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q6NSI3; gene symbol FAM53A.
- Organism: Homo sapiens.
- Length: 398 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and osteoarthritis, hip.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein FAM53A |
|---|---|
| UniProt accession | Q6NSI3 |
| Gene | FAM53A |
| Organism | Homo sapiens |
| Length | 398 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- mean corpuscular volume · score 0.13
- osteoarthritis, hip · score 0.12
- osteoarthritis, knee · score 0.12
- cortical surface area measurement · score 0.09
- neuroimaging measurement · score 0.09
- osteoarthritis · score 0.08
- mean reticulocyte volume · score 0.07
- lean body mass · score 0.07
- appendicular lean mass · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NSI3-F1 | alphafold | PREDICTED | 52.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NSI3.
Amino-acid sequence (398 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM53A?
The strongest Open Targets associations for FAM53A are neurodegenerative disease, mean corpuscular volume, osteoarthritis, hip, osteoarthritis, knee and cortical surface area measurement.
How long is the FAM53A protein?
The Homo sapiens FAM53A protein (UniProt Q6NSI3) is 398 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NSI3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NSI3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.