SANT and BTB domain regulator of class switch recombination (SANBR)
Homo sapiens — UniProt Q6NSI8
Data last refreshed: (UniProt release unknown)
Key facts
SANT and BTB domain regulator of class switch recombination (SANBR) is a protein from Homo sapiens identified by UniProt accession Q6NSI8, 718 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q6NSI8; gene symbol SANBR.
- Organism: Homo sapiens.
- Length: 718 amino acids.
- Top disease associations (Open Targets): lymphocyte count, peroxisome biogenesis disorder 11A (Zellweger) and Zellweger syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SANT and BTB domain regulator of class switch recombination |
|---|---|
| UniProt accession | Q6NSI8 |
| Gene | SANBR |
| Organism | Homo sapiens |
| Length | 718 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.40
- peroxisome biogenesis disorder 11A (Zellweger) · score 0.33
- Zellweger syndrome · score 0.33
- multiple sclerosis · score 0.21
- neuroticism measurement · score 0.13
- skin disease · score 0.08
- reticulocyte count · score 0.08
- reticulocyte measurement · score 0.06
- Immature Reticulocyte Fraction Measurement · score 0.06
- atopic eczema · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NSI8-F1 | alphafold | PREDICTED | 67.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NSI8.
Amino-acid sequence (718 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SANBR?
The strongest Open Targets associations for SANBR are lymphocyte count, peroxisome biogenesis disorder 11A (Zellweger), Zellweger syndrome, multiple sclerosis and neuroticism measurement.
How long is the SANBR protein?
The Homo sapiens SANBR protein (UniProt Q6NSI8) is 718 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NSI8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NSI8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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