Pleckstrin homology-like domain family B member 3 (PHLDB3)
Homo sapiens — UniProt Q6NSJ2
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology-like domain family B member 3 (PHLDB3) is a protein from Homo sapiens identified by UniProt accession Q6NSJ2, 640 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q6NSJ2; gene symbol PHLDB3.
- Organism: Homo sapiens.
- Length: 640 amino acids.
- Top disease associations (Open Targets): platelet count, cancer and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology-like domain family B member 3 |
|---|---|
| UniProt accession | Q6NSJ2 |
| Gene | PHLDB3 |
| Organism | Homo sapiens |
| Length | 640 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- platelet count · score 0.20
- cancer · score 0.07
- calcium measurement · score 0.06
- appendicular lean mass · score 0.04
- neoplasm · score 0.04
- body height · score 0.04
- low density lipoprotein cholesterol measurement · score 0.02
- tuberculosis · score 0.01
- metastatic melanoma · score 0.01
- Invasive Breast Carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NSJ2-F1 | alphafold | PREDICTED | 68.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NSJ2.
Amino-acid sequence (640 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHLDB3?
The strongest Open Targets associations for PHLDB3 are platelet count, cancer, calcium measurement, appendicular lean mass and neoplasm.
How long is the PHLDB3 protein?
The Homo sapiens PHLDB3 protein (UniProt Q6NSJ2) is 640 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NSJ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NSJ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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