Volume-regulated anion channel subunit LRRC8E (LRRC8E)
Homo sapiens — UniProt Q6NSJ5
Data last refreshed: (UniProt release unknown)
Key facts
Volume-regulated anion channel subunit LRRC8E (LRRC8E) is a protein from Homo sapiens identified by UniProt accession Q6NSJ5, 796 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q6NSJ5; gene symbol LRRC8E.
- Organism: Homo sapiens.
- Length: 796 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): neurodegenerative disease, sex hormone-binding globulin measurement and serum alanine aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Volume-regulated anion channel subunit LRRC8E |
|---|---|
| UniProt accession | Q6NSJ5 |
| Gene | LRRC8E |
| Organism | Homo sapiens |
| Length | 796 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- sex hormone-binding globulin measurement · score 0.25
- serum alanine aminotransferase measurement · score 0.13
- lean body mass · score 0.06
- high density lipoprotein cholesterol measurement · score 0.06
- appendicular lean mass · score 0.05
- whole body water mass · score 0.05
- base metabolic rate measurement · score 0.04
- C-reactive protein measurement · score 0.04
- breast carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NSJ5-F1 | alphafold | PREDICTED | 84.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NSJ5.
Amino-acid sequence (796 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC8E?
The strongest Open Targets associations for LRRC8E are neurodegenerative disease, sex hormone-binding globulin measurement, serum alanine aminotransferase measurement, lean body mass and high density lipoprotein cholesterol measurement.
How long is the LRRC8E protein?
The Homo sapiens LRRC8E protein (UniProt Q6NSJ5) is 796 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NSJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NSJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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