MRN complex-interacting protein (MRNIP)
Homo sapiens — UniProt Q6NTE8
Data last refreshed: (UniProt release unknown)
Key facts
MRN complex-interacting protein (MRNIP) is a protein from Homo sapiens identified by UniProt accession Q6NTE8, 343 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q6NTE8; gene symbol MRNIP.
- Organism: Homo sapiens.
- Length: 343 amino acids.
- Top disease associations (Open Targets): osteitis deformans, frontotemporal dementia and/or amyotrophic lateral sclerosis 1 and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | MRN complex-interacting protein |
|---|---|
| UniProt accession | Q6NTE8 |
| Gene | MRNIP |
| Organism | Homo sapiens |
| Length | 343 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- osteitis deformans · score 0.34
- frontotemporal dementia and/or amyotrophic lateral sclerosis 1 · score 0.27
- neutrophil count · score 0.20
- leukocyte count · score 0.17
- neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset · score 0.12
- azoospermia · score 0.09
- aspartate aminotransferase measurement · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- appendicular lean mass · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6NTE8-F1 | alphafold | PREDICTED | 56.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6NTE8.
Amino-acid sequence (343 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRNIP?
The strongest Open Targets associations for MRNIP are osteitis deformans, frontotemporal dementia and/or amyotrophic lateral sclerosis 1, neutrophil count, leukocyte count and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset.
How long is the MRNIP protein?
The Homo sapiens MRNIP protein (UniProt Q6NTE8) is 343 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6NTE8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6NTE8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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